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KMID : 0381920090390020133
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Korean Journal of Microscopy
2009 Volume.39 No. 2 p.133 ~ p.139
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The Food Safety of Superfine Powder (Phellinus linteus) Processed by Nanomill in C57BL/6 Mice
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Abstract
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A officinal mushroom, Phellinus linteus (PL) has been known to exhibit potent biological activities including antioxidative and anticancer effect. PL is consumed as a type of powder or extract for the purpose of health promotion and disease treatment. Recently superfine PL products was commercialized according to the development of pulverizing technology such as nanomill, so the evaluation of food safety is suggested. This study was conducted to evaluate the food safety of superfine PL (SPL) through hematological, biochemical and histological examination in mice as compared with fine PL (FPL). In the particle size distribution in volume after nanomill processing, the mean diameter of SPL and FPL particles was 11.78 μm and 216.1 μm, and d (0.5), the particle diameter measured at 50% of distribution was 5.5 μm and 147.9 μm, respectively. As the result of body weight, food intake and the weight of organs, SPL group didn’t show any statistical difference compared with FPL group and normal group (N). Hematological and biochemical values were also involved in the normal range, although ALT (N vs. FPL, P?0.001) and BUN (N vs. FPL, P?0.01; N vs. SPL, P?0.01) showed significance compared with N group but there are no significance between FPL and SPL group. In the result of histological examination with liver, kidney, spleen, and small and large intestine, abnormal findings such as inflammatory reaction and histological changes were not observed. Our results suggest that the oral intake of SPL diet is not harmful to the animal in the hematological, biochemical and histological aspects although particle size was reduced to the level of superfine. However, further study will be necessary to confirm the histological safety in relation to the gastrointestinal contact of superfine particles in the case of large amount and long-term intake.
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KEYWORD
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Phellinus linteus, Food safety, Superfine, In vivo
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